Seasonal and part time jobs
Background Joints in our body are fascinating systems, both mechanically and biologically. Their proper function is a result of a fine interplay between cartilage tissues covering the bones in a contact and various biomolecules present in the synovial fluid within the capsule around the joint. The cartilage tissues may be affected by a number of degenerative diseases, such as osteoarthritis, leading to a significant decline in the joint function and a loss of mobility. One of the risk factors for joint diseases is a high age and therefore, with the growing age of the world population there is an increasing need for development and testing of novel treatments that can alleviate suffering that joint diseases bring along. Pharmacological formulations for treatment of joint diseases are often delivered directly into the joint capsule. The response to such treatment is often followed by clinical studies evaluating symptoms such as mobility, pain and occurrence of infection and inflammation. However, there is little known about the local mechanism of action of these formulations, such as effect on the friction between cartilage surfaces, adsorption of components at the surfaces or interactions with molecules present in synovial fluid. Also, little is known about how joint movement/friction and compression/decompression under load affects the penetration of active drug compounds into cartilage tissues. Ex-vivo models for pre-clinical testing of these aspects are desirable, since they would reduce the number of necessary animal tests as well as enable better understanding of the various processes following an injection of a drug formulation into the joint. The project: The goal of the master project is to set up and test a model system for evaluation of mammalian articular joint lubrication following a drug injection. In particular: • To develop a methodology for attachment and use of ex-vivo animal cartilage tissues with tribological instruments available in our laboratory such as Force Board, Mini Traction Machine or Texture Analyser. • To test the developed set-up by collecting lubrication data using simple lubricant liquids, such as buffer and a model synovial fluid. • To analyse importance of parameters such as cartilage tissue thickness, hydration, mechanical properties and surface roughness on the resulting lubrication Besides the tribological methods, the project may also involve work with Optical Microscopy, Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) for characterisation of topography and mechanical properties of the cartilage tissues. Your work will be performed at the Research Institutes of Sweden (RISE), Division of Bioscience and Materials, at Drottning Kristinas väg, situated nearby the main KTH campus. Previous experience in research activity is appreciated; however, the most important will be your genuine interest and motivation. The work can result in a scientific publication, co-authored by you. For more information about the project, please contact: Associate Prof. Andra Dedinaite, Division for Surface and Corrosion Science, KTH: firstname.lastname@example.org Dr. Lubica Macakova, Division for Bioscience and Materials, RISE: email@example.com For more information about RISE Research Institutes of Sweden, please check https://www.ri.se and for information about the Division for Surface and Corrosion Science at KTH see https://www.kth.se/en/che/divisions/surfcorr/yt-och-korrosionsvetenskap-1.520298
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Deadline for application
KTH: Andra Dedinaite, firstname.lastname@example.org RISE: Lubica Macakova, email@example.com
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